![]() Most neonatal seizures are focal and subtle. Prolonged seizures can also result in impaired neurodevelopment or even death (Celka et al., 2001). Delay in the diagnosis and treatment of untreated prolonged seizures may result in long-term neurological damage (Holmes and Ben-Ari, 2001). Early-onset epilepsy can severely interfere with both language and social development in developing newborns, who may be impaired in other domains including coordination, cognition, and behavior (Arzimanoglou and Goutières, 1996). The majority of neonatal seizures occur within the first few days of life, with an incidence between 1.8 and 3. Due to brain immaturity, neonates are more prone to epileptic seizures (Volpe, 2000). ![]() An epileptic seizure is an abnormal hypersynchronous discharge of cortical neuronal populations (Hauser et al., 1996). ![]() Epilepsy is a neurological disorder that affects 1% to 3% of the world’s population. ![]()
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